ECF Fellow Presents: How to Save Eyes in Cairo, Egypt

Dr. Abhilasha Maheshwari (above) presents ECF research at Ophthalmic Oncology Meet

November 22nd Cairo, Egypt:
Physician scholars came together for The 2nd Middle East Ophthalmic Oncology & Pediatric Retina Meeting. Organized by Dr. Ihab Othman, the meeting fostered discussion of various topics in ocular oncology.

The Eye Cancer Foundation (ECF) fellow, Dr. Abhilasha Maheshwari, shared recent findings of ECF supported research. She first presented a talk covering Regression Patterns of Iris Melanoma After Palladium-103 (Pd-103) Plaque Brachytherapy. Originally researched by ECF-Fellow Dr. Sonal Chaugule and ECF-Chair, Dr. Paul T. Finger, this study shows how iris melanomas regress after Pd-103 plaque radiation therapy. First described by Dr. Finger, this type of iris melanoma irradiation allows doctors to preserve normal iris tissue and function. (See our results after Pd-103 plaque for iris and ciliary body melanomas on our web site here.) Results showed the tumors became darker, decreased in thickness and there was a reduction or complete elimination of the tumor vascularity.

Then, Dr. Maheshwari presented her own research performed with Dr. Finger. This study, A 12-Year Study of Slotted Palladium-103 (Pd-103) Radiation Therapy for Choroidal Melanoma: Near, Touching, or Surrounding the Optic Nerve, shows that by using Dr. Finger’s specially designed “slotted” plaques, even melanomas that surround the optic nerve can be treated with eye and vision-sparing radiation therapy (instead of removing the eye). Dr. Maheshwari’s results indicated > 98% tumor control, while most had relative preservation their sight and eye.

The Eye Cancer Foundation takes great pride supporting research that improves patient care. Our fellows are given travel grants to spread the word around the world. As we spread knowledge of these unique findings and improved treatments, we also spread hope for those who would alternatively lose both sight and life.

 


 

To donate to the ECF and help sponsor fellowships, research, and cancer treatments, click here!

Read Dr. Finger and Dr. Chagule’s paper here.

Read Dr. Finger and Dr. Maheshwari’s paper here.


Trailblazing Eye Cancer Studies Presented at AAO 2017

 

As you may have heard in our previous blog, the American Academy of Ophthalmology (AAO) 2017 Meeting in New Orleans, Louisiana was attended by noteworthy fellowship alumni from the Eye Cancer Foundation, as well as founder and executive director of the ECF, Dr. Paul T. Finger. Held from November 11th to 14th, AAO took place the day following the 2017 AAOOP Annual Meeting, where oral presentations were given by ECF Fellows Dr. Sonal Chaugule and Dr. Abhilasha Maheshwari.

Dr. Chagule spoke on her research regarding the efficiency of intravitreal steroids to treat radiation side-effects, while Dr. Maheshwari spoke on a 12-year study of patients treated with slotted plaque radiation therapy. To read more on AOOP 2017 presentations from these ECF fellows, click here.

At AAO 2017, hosted at the Ernest N. Morial Convention Center in New Orleans, Dr. Sonal Chaugule, Dr. Ekatrina Semenova, and Dr. Nicole Scripsema presented ECF-sponsored research conducted under the guidance of Dr. Paul T. Finger at the New York Eye Cancer Center and at New York Eye and Ear Infirmary.

Dr. Sonal, pictured below along Dr. Finger, presented two studies, the first titled “Regression patterns of Iris Melanoma after Palladium-103 Plaque Brachytherapy”. This study takes into account 50 iris melanoma patients who were closely evaluated following plaque brachytherapy with Palladium-103 as treatment. The results of this study underscored Palladium-103 as effective treatment for iris melanoma. After incisive evaluation, patients showed decreases in tumor size, tumor pigmentation, and more. These findings are particularly important to iris melanoma patients, who endure a rare condition in the already-rare family of cancers (iris melanoma patients are only 2-3% of eye cancer cases). To read more on this paper and its implications, click here.

Dr. Chaugule’s second presentation concerned her paper most-recently published in the Indian Journal of Opthalmology. Titled “Primary Topical Chemotherapy for Giant Ocular Surface Squamous Neoplasia”, this paper examines and reports the outcomes of using topical chemotherapy eye drops (such as 5-Flurouracil and/or Interferon alpha-2b) to treat giant ocular surface squamous neoplasia. The paper was featured in a past blog post — to read more on the study, which evaluated 10 patients with stage T3 tumors, click here.

Details from AAO do not stop here! Stay tuned for more exciting news on the work ECF Fellows make towards eye cancer research by keeping eyecancer.com in your bookmarks!


AAO Newsletter Features Paper Published by ECF Fellow

From the summer of 2016 to 2017, Dr. Sonal S. Chaugule gained a wealth of knowledge as an Eye Cancer Foundation (ECF) fellow under the tutelage of Dr. Paul T. Finger at the NYECC. From shadowing Dr. Finger’s surgeries at the New York Eye and Ear Infirmary, to speaking at the Second Eye Cancer Working Day in March 2017, Dr. Chaugule has since returned to India, using the knowledge she has gained as tools to continue in the footsteps of her mentors. Her efforts manifest in her paper, in collaboration with Dr. J. Park and Dr. Paul Finger, being published by the American Academy of Ophthalmology.

Featured in the headlines of the AAO Newsletter, the paper was first published by the Indian Journal of Ophthalmology in December 2017, and discusses the effectiveness and safety of topical chemotherapy as sole treatment for giant ocular surface squamous neoplasia (OSSN). Ten patients (3 female, 7 male) with biopsy-confirmed giant OSSN were treated with topical chemotherapy drops (interferon alpha 2b and/or 5 flurouracil 1%). Then, patients were monitored for changes in tumor response, vision, recurrence of disease, metastasis, and treatment complications.  

Pictured below are samples from the paper, revealing slit-lamp photographs of patients afflicted with OSSN before treatment (A, C) and after treatment (B, D). Pre-treatment for both patients (A, C) and post-treatment (B, D) reveal complete tumor regression after treatment via topical chemistry therapy drops. You may note that there is no evidence of opacity, or haziness, to the cornea in the after photos.

Results found that there was no evidence of vision-limiting complications due to treatment by chemotherapy drops — no thinning of the sclera (the white of the eye), no cloudiness in the cornea, and no stem cell deficiency. Noteworthily, there were no tumor recurrences, and none of these 10 patients required additional treatment for their giant OSSN such as surgical excision or cryotherapy. For all patients in this study, there was tumor regression, concluding to researchers that topical chemotherapy drops were not only safe, but effective as treatment for giant OSSN. To read the published study in full, click here.

 

The ECF offers fellowships to doctors from unserved and underserved countries, providing specialized training in the treatment of retinoblastoma and other eye cancers. Once they complete their training, ECF fellows commit to return home to create eye cancer treatment programs. Dr. Chaugule has begun oncology services at HV Desai Eye Hospital in Pune, India, a vital center for eye cancer research and patient treatment, serving a wide population of not only Indians, but also those from the neighboring countries of Pakistan, Bangladesh, and Nepal.   

Through its  2020 Campaign, The Eye Cancer Foundation plans to multiply this success story across the world. With your help, we can train 20 eye cancer specialists to work in 20 countries by 2020.

Our immediate 2020 Campaign goal is to save the lives of 1,000 children by 2020. But that’s only the beginning. Our ability to train doctors and supply them with the equipment they need to properly diagnose and treat retinoblastoma is only limited by the generosity of our donors.

You can become part of the cure with a one-time or recurring donation to The Eye Cancer Foundation. Click HERE to donate today.


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