Compare the Results of Iodine-125, Ruthenium-106 and Palladium-103 Plaques

Eye Plaque Results: Treatment of Choroidal Melanoma

In a (2009) publication*, Dr. Finger created a table summarizing the results of the largest major clinical studies of radiation for choroidal melanoma at approximately 5 years follow up.

Chart: Comparison of Results after Plaque Radiation Therapy

(Click to Enlarge and View the Full Chart)

Overview Reference

  • Radiation Therapy for Choroidal Melanoma. Finger PT.
    Survey of Ophthalmology (Review Article) 42:215-32, 1997
  • Palladium-103 ophthalmic plaque radiation therapy for choroidal melanoma: 400 treated patients. Finger PT, Chin KJ, Duvall G for The Palladium-103 for Choroidal Melanoma Study Group. Ophthalmology 2009;116:790-6.


  1. Melia BM, Abramson DH, Albert DM, et al. Collaborative ocular melanoma study (COMS) randomized trial of I-125 brachytherapy for medium choroidal melanoma. I. Visual acuity after 3 years. COMS report No. 16. Ophthalmology. 2001;108:348-366.
  2. Jampol LM, Moy, CS, Murray TG, et al. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: IV. Local treatment failure and enucleation in the first 5 years after brachytherapy. COMS report no. 19. Ophthalmology. 2002 Dec;109(12):2197-206.
  3. Collaborative Ocular Melanoma Study Group. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognostic factors: COMS report No. 28. Arch Ophthalmol. 2006 Dec;124(12):1684-93.
  4. Packer S, Stoller S, Lesser ML, et al. Long-term results of iodine 125 irradiation of uveal melanoma. Ophthalmology. 1992;99:767-774.
  5. Fontanesi J, Meyer D, Xu S, et al. Treatment of choroidal melanoma with I-125 plaque. Int J Radiat Oncol Biol Phys. 1993;26:619-623.
  6. Lommatzsch PK. B-irradiation of choroidal melanoma with 106-Ru/106-Rh applicators: 16 years’ experience. Arch Ophthalmol. 1983;101:713-717.
  7. Gragoudas ES, Seddon JM, Egan K, et al. Long-term results of proton beam irradiated uveal melanomas. Ophthalmology. 1987 Apr;94(4):349-53.
  8. Char DH, Kroll SM, Castro J. Ten-year follow up of helium ion therapy for uveal melanoma. Am J Ophthalmology 1988:125:81-9.
  9. Brokvina AF, Zarubei GD. Ciliochoroidal melanomas treated with a narrow medical proton beam. Arch Ophthalmol 1986;104:402-4.
  10. Finger PT, Chin KJ, Duvall BS for The Palladium-103 for Choroidal Melanoma Study Group. Palladium-103 Ophthalmic Plaque Radiation Therapy for Choroidal Melanoma: 400 Treated Patients. Ophthalmology 2009;116:790-6.

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