By Paul T. Finger, MD
There are two main types:
Congenital retinal pigment epithelial hypertrophy (CHRPE) is usually found before patients reach 30 years of age. They may enlarge with time, but are not commonly associated with malignant transformation. There has been an association made between people with Gardner’s Syndrome (familial colonic polyposes) and CHRPE.
If your eye care specialist has told you that you have congenital retinal pigment epithelial hypertrophy, it is reasonable to tell your gastroenterologist so that he may recommend the frequency of your colon screening tests.
Acquired retinal pigment epithelial hypertrophy is typically found later in life. They are typically jet-black to gray, flat, with a halo around its edges. They are variable in size, and may develop lacunae of lightly colored areas of atrophy (see above). These tumors are more commonly found in the peripheral retina where thickness is more difficult to judge by ophthalmoscopy.
Almost all patients with retinal pigment epithelial hypertrophy do not have symptoms. These pigmented intraocular lesions are found by eye care specialists during dilated examination of the inside of the eye (ophthalmoscopy). Eye tumor specialists can differentiate between retinal pigment epithelial hypertrophy and melanoma by clinical examination (without a biopsy).
Retinal pigment epithelial hypertrophy can be diagnosed by ophthalmic examination. This will include a careful history for familial colon disease (polyposes). The eye examination will concentrate on the appearance of the retinal pigment epithelial hypertrophy. These lesions tend to be black or atrophic. They may be surrounded by a halo of less pigmented tissue or exhibit a sharp demarcation line.
Ultrasonography typically shows that RPE hypertrophy is flat to minimally elevated and slightly hyper-reflective.
Fluorescein angiography of RPE hypertrophy typically demonstrates blockage of fluorescence (except in the areas of atrophy which are hyperfluorescent).
Optical coherence tomography (OCT) of RPE hypertrophy will demonstrate thickening of the RPE with areas of thinning (atrophy). The underlying choroid is typically attenuated (thinner).
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